BLOCK LISTING SIX MONTHLY RETURN

Name of applicant:

Shire plc

Name of scheme:

Shire Sharesave Scheme

Period of return:

From:

November 23, 2015

To:

 May 22, 2016

Balance of unallotted securities under scheme(s) from previous return:

201,916

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

17,003

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

184,913

Name of applicant:

Shire plc

Name of scheme:

Shire Portfolio Share Plan

Period of return:

From:

November 23, 2015

To:

May 22, 2016

Balance of unallotted securities under scheme(s) from previous return:

1,520,106

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

315,755

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

1,204,351

Name of applicant:

Shire plc

Name of scheme:

Shire Employee Stock Purchase Plan

Period of return:

From:

November 23, 2015

To:

May 22, 2016

Balance of unallotted securities under scheme(s) from previous return:

249,227

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

4,776

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

244,451

Name of applicant:

Shire plc

Name of scheme:

Shire Long Term Incentive Plan 2015

Period of return:

From:

November 23, 2015

To:

May 22, 2016

Balance of unallotted securities under scheme(s) from previous return:

2,991,240

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

35,368

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

2,955,872

Name of applicant:

Shire plc

Name of scheme:

Shire Global Employee Stock Purchase Plan

Period of return:

From:

November 23, 2015

To:

May 22, 2016

Balance of unallotted securities under scheme(s) from previous return:

2,000,000

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

31

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

1,999,969

Name of contact:

Sarah Howfield, Assistant Company Secretary

Telephone number of contact:

01256 894000

Investor Relations

Sarah Elton-Farr

[email protected]

+44 1256 894157