Block Listing Six Monthly Return

Name of applicant:

Shire plc

Name of scheme:

2000 Executive Share Option Scheme

Period of return:

From:

November 23, 2014

To:

May 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

3,406,623

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

Nil

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

3,406,623*

Name of applicant:

Shire plc

Name of scheme:

Shire Sharesave Scheme

Period of return:

From:

November 23, 2014

To:

May 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

207,758

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

4,207

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

203,551

Name of applicant:

Shire plc

Name of scheme:

Shire Portfolio Share Plan

Period of return:

From:

November 23, 2014

To:

May 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

1,138,214

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

2,000,000

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

1,353,145

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

1,785,069

Name of applicant:

Shire plc

Name of scheme:

Shire Employee Stock Purchase Plan

Period of return:

From:

November 23, 2014

To:

May 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

524,710

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

2,373

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

522,337

Name of applicant:

Shire plc

Name of scheme:

Shire Long Term Incentive Plan 2015

Period of return:

From:

May 13, 2015

To:

May 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

Nil

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

3,000,000

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

Nil

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

3,000,000

Name of contact:

Tony Guthrie, Deputy Company Secretary

Address of contact:

Hampshire International Business Park

Basingstoke, Hampshire, RG24 8EP

Telephone number of contact:

01256 894746

Investor Relations

Sarah Elton-Farr

[email protected]

+44 1256 894157