Block listing six monthly return

Name of applicant:

Shire plc

Name of scheme:

Shire Sharesave Scheme

Period of return:

From:

May 23, 2015

To:

 November 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

203,551

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

1,635

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

201,916

Name of applicant:

Shire plc

Name of scheme:

Shire Portfolio Share Plan

Period of return:

From:

May 23, 2015

To:

November 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

1,785,069

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

264,963

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

1,520,106

Name of applicant:

Shire plc

Name of scheme:

Shire Employee Stock Purchase Plan

Period of return:

From:

May 23, 2015

To:

November 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

522,337

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

273,110

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

249,227

Name of applicant:

Shire plc

Name of scheme:

Shire Long Term Incentive Plan 2015

Period of return:

From:

May 23, 2015

To:

November 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

3,000,000

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

Nil

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

8,760

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

2,991,240

Name of applicant:

Shire plc

Name of scheme:

Shire Global Employee Stock Purchase Plan

Period of return:

From:

November 2, 2015

To:

November 22, 2015

Balance of unallotted securities under scheme(s) from previous return:

Nil

Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):

2,000,000

Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):

Nil

Equals:  Balance under scheme(s) not yet issued/allotted at end of period:

2,000,000

Name of contact:

Oliver Strawbridge, Senior Assistant Company Secretary

Telephone number of contact:

01256 894000

Investor Relations

Matthew Osborne

[email protected]

+1 781 482 9502

Sarah Elton-Farr

[email protected]

+44 1256 894157